I go against recommended practice and have different vaults for different things in my life. The academic note vault is separate from the personal vault is separate from the creative projects vault. I have also committed sacrilege by not having many notes linked to each other. I’m trying to migrate a lot of notes from Google Docs and Notion over into Obsidian, so all of the vaults are pretty messy.
I love the LaTeX integration. Lots of math formulas in the academic note vault. I use the callout feature everywhere. I also nest callouts in callouts. I’m frankly treating them as equivalent to toggles in Notion.
I most often go to the personal vault where I have a list of things I’ve 1) seen online before, 2) spent at least an hour trying to refind that thing later and 3) will probably want to find again. This way I don’t lose time trying to find it again. It’s really helpful for me. I also have a list of food brands and how much I liked them, so I can remember which brand of turkey was bad and which was tolerable and which I’d definitely buy again.
I started with one vault, but slowly broken it apart to several. Now I have a lot of reasonably sized vaults for various topics.
I like having separate vaults because it creates mental focus on what I want to work on.
I have a general/personal vault, but when trying to ramp up on topics, I also have research related vaults.