The reconstructed Neanderthal flute has a capability of 3½ octaves and all contemporary music genres can be played on it. It is possible to perform a series of musical articulations and ornamentations such as legato, staccato, double and triple tonguing, flutter-tonguing, glissando, chromatic scales, trills, broken chords, interval leaps, and melodic successions from the lowest to the highest tones (via Wikipedia)

There is also a video of Ljuben Dimkaroski playing a replica of the flute.