A new version of the popular diabetes treatment Mounjaro can be sold as a weight-loss drug, U.S. regulators announced Wednesday.
The U.S. Food and Drug Administration approved Eli Lilly’s drug, named Zepbound. The drug, also known as tirzepatide, helped dieters lose as much as 40 to 60 pounds in testing.
The track record for weight loss drugs is not good. Even “approved” ones. We had a lot of teenagers on amphetamines to make them lose weight.
The podcast Maintenance Phase has at least one episode on them and their history.
The results for this and Wegovy are pretty promising. That said, the long term effects are unknown since they are so new. But the long term effects of having a BMI over 30 are pretty terrible and well known. These are nothing like amphetamines.
The results are that they were only tested on perfectly healthy people which is not indicative of their success in the general population, and the results were also that most people gained the weight back immediately upon stopping the drug.
The side effects were not too bad for people getting the drug for free, but at 1k a month, those side effects cause much higher drop out rates as well.
Still way more promising than anything else available, but not that promising overall.
Eh these people are either gonna be taking bp/cholesterol/diabetes medication or this. Seems like it has the potential to be a wash?
I’m personally a big fan of consuming fewer calories.
Great point, how do you think weight loss drugs work?
They make you less hungry or curb your cravings… Making you eat less.
Not all of them. Some of these drugs can affect nutrient uptake, others are amphetamines to make your resting energy use rise, as a stimulant. I’m sure there are other mechanisms to mess with as well.
Amphetamines basically make you not hungry. That is the primary mechanism anyway.
Or you can just eat less
But can you? When your body is constantly screamming eat more. Those who can assume everyone can, but not everyone can.
I believe yes. I think it’s hard but I think you can. Weight loss drugs, liposuction, stomach stapling, etc none of those methods helps someone learn to control their cravings or redirect their cravings. We live in a world of excess. There’s food everywhere you turn. It’s like a recovering alcoholic. He or she needs to learn to live in a world where alcohol is omnipresent but they have chosen to not indulge their inner cravings. Someone can be craving horrible food and choose to eat salads without creamy dressing. You can choose to not drink sugary drinks. You can crave ice cream but choose to eat raw carrots instead. Is it as fun? No. But alcoholics walk by bars and liquor stores every single day and they choose to not indulge their cravings. It isn’t as fun but they do it regardless.
To use your alcoholic analogy. Imagine you were a terrible alcoholic and you decide to get better. Great! But you can’t STOP drinking. Not completely. You have to stop drinking too much while also NEEDING to have 2-3 single drinks a day to survive. So every day. Every. Single. Day. Multiple times a day you have to face that temptation. Your brain and body are craving you down a fifth of vodka when you wake up, but you’re only supposed to drink a watered down Bloody Mary instead. You have to taste that vodka and get a tiny bit of that dopamine hit from it, but you just have to stop. Your kitchen is full of liquor bottles, but you have to just wait until lunch to have your next drink with that craving eating away at you.
And then you hit the breakroom at lunch to sip on your small shot of whiskey you brought from home, but the breakroom is a cocktail bar and everyone around you is downing a couple pints of lager or a Long Island Ice Tea. There’s an open bar right there! Plenty of drinks easily available and your mind is begging you to just go get some. But you’re not abstaining completely. You just have to sit there and sip on your tiny bit of alcohol and that’ll just be enough.
For your nightly drink, you always take it at home. You can’t go to a restaurant with anyone, or even by yourself. You can’t order in. The smallest drinks they serve is a full pint. And still, while you down that Manhattan as quickly as you can every night so as not to think about it too much, you have to go to your kitchen to prepare it with the shelves full of liquor. And just have that one drink. Everyone else gets to have a few drinks a day and move on with their life, but for you every meal is a fight to not go off the deep end while dipping your toes just a little into the pool.
And then tomorrow you have to wake up and do it again.
And every day for the rest of your life.
And that’s just me trying to appeal to your empathy, assuming you have any. There’s science that shows that the dopamine (or maybe serotonin, I always get them confused) that food addicts get is just as addictive as a hard drug habit. It’s literally the same thing. That’s why drugs feel good. It’s not just the altered state that’s addictive. The chemicals your brain release when it gets these things make you crave more. Some people’s brains light up from eating some foods. It’s the same thing as a drug habit, but you can’t quit. Ever. There’s science to back up how wrong you are. You just don’t have to deal with it and you can’t imagine how anyone could have different experiences than you.
My favorite part of this is your assumption that I have no personal experience in any of this. I know that it’s hard. I also know it’s possible to stop drinking and stop eating to excess. These are not analogies for me.
That’s like telling depressed people “just don’t be so down”. It shows a lack of empathy as well as medical ignorance.
No it isn’t. You can’t choose to not be depressed but you can choose to eat less and accomplish it through willpower.
Where does willpower come from?
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‘lmao like how are people homeless, just get a house’
People can have self control. It’s possible through nothing more than willpower to choose to eat less and just do it. Just like how there are people who choose to stop drinking alcohol. They chose to be sober and then they worked at being sober. Some people get help with support groups but there are a lot of sober people who just chose to stop drinking. People can infact choose to eat less. I’m not saying it isn’t hard but it is possible. No one can choose to have a house through willpower alone.
You can downvote me all you want. It doesn’t bother me in the slightest. Because I think it’s so incredibly weird how every little imperfection now needs the pharmaceutical industry to sell you a pill to fix it. Medicine is one thing. Antipsychotics, schizophrenia, ADHD medications, etc. there are plenty of things that require medication. But weight loss? Come on. Unless you have some diagnosed underlying condition, which I imagine is rather rare, then you don’t need a pill to lose weight. You are capable of doing on your own.
Yeah, just like homeless people can just get a house, overweight people can just eat less. Simple shit with no more nuance whatsoever. No need for any deeper investigation of these complex topics. Let’s keep minimizing both of these groups without any form of empathy like the piles of shit we make ourselves out to be.