If you pick a base character then the prime gets removed as well, the better version cant exist without the base version, however if you remove a prime version then the base character can still exist. My personal pick would be Valkyr due to how [IMO] useless she seems
I’m one of the probably 6 people who actually genuinely like Inaros, but he’s definitely the character I think people would miss the least if I had to pick a frame.